Welcome to the Sekelsky lab website! For more than 25 years, diverse trainees at all career stages in our lab in the Department of Biology and the Integrative Program for Biological and Genome Sciences at the University of North Carolina at Chapel Hill, have been doing creative science investigating mechanisms and control of recombination in meiosis and mitosis, in an interactive, supportive, and enjoyable atmosphere. Use the links below to learn more.
Recent News
July 31, 2024
Everyone in the lab was on hand to say goodbye to Dr. Evan Dewey, who leaves to start a tenure-track
faculty position at Winthrop University. It was no surprise that all the undergraduates came, as Evan
was a dedicated mentor to a large number of undergraduate researchers, as well as three high school students from the
North Carolina School of Science and Math.
July 26, 2024
Charlene completed the six week WinSPIRE program, mentored by Priscila.
Charlene's results provide insights into impacts of chromatin state on mitotic recombination.
She explained her results through her poster at the WinSPIRE poster session.
April 1, 2024
Grey wrote a Senior Honors Thesis based on her research under the direction of Priscila. She presented her findings at the John J. Koeppe Honors Symposium.
Her talk generated several good questions, which she answered expertly. Grey's thesis is titled "Changes in Chromatin Structure Affect Mitotic
Recombination Frequence in Drosophila melanogaster."
Emerson's thesis is titled "RING Finger Proteins
in Crossover Designation and Interference."
Jan 3, 2024
Nila's paper on mechanisms of suppression of crossovers in
centromere-proximal regions was accepted for publication in Genetics!
Nila altered the number of centromeres and the amount of satellite DNA sequence, and disrupted meiotic centromere clustering (image).
She found that the suppression of meiotic crossovers persists despite these changes.
November 8, 2023
Reese wrote a Senior Honors Thesis titled "Homologous Recombination Repair in the Context of CRISPR/Cas9-Mediated DNA Double-Stranded
Breaks in Drosophila." She presented her findings at the John J. Koeppe Honors Symposium. Reese did an outstanding job of making
a difficult topic (recombination models) understandable for a broad audience.
April 20, 2023
Shaelin Lee and Koki presented posters on the research they conducted this summer. Shaelin, mentored by Nila participated in the
SURE summer research program.
Koki, mentored by Evan, was part of the SPIRE summer research program. They now
return to their home institutions (U. Georgia for Shaelin, UNC Pembroke for Koki).
March 12, 2023
Jeff received the Award for Excellence in Graduate Student Support and Program Management from The Graduate School.
This award, based on nominations from students, recognizes contributions as a Director of Graduate Studies, a role Jeff held for 10 years in the
Curriculum in Genetics and Molecular Biology.
Nov 7, 2022
Juan Carvajal-Garcia, who graduated last spring and then moved on to do postdoctoral research in the lab of Houra Merrikh
at Vanderbilt, was selected to receive a postdoctoral resaerch fellowship from the Helen Hay Whitney Foundation.
Sept 2, 2022
Evan's paper titled "Effect of repeat length on Marcal1-dependent single-strand annealing in Drosophila was published in GENETICS.
Evan and co-authors Julie Korda Holsclaw (former postdoctoral fellow), Kiyarash Saghey and Mackenzie Wittmer (both former undergraduate researchers) investigated the
length requirements for single-strand annealing repair of double-strand breaks. They find differences from yeast, which uses Rad52 versus Marcal1 in Drosophila.
The results also provide guidance for lengths of homology arms used in SSA-based CRISPR/Cas9 genome integration.
Aug 7, 2022
Nila was awarded an NRSA F31 fellowship from the National Institute on Aging of the National Institutes of Health. Her proposal, titled
"Mechanisms and regulation of meiotic recombination," will be funded for three years (unless she completes her PhD before the end of that time!).
July 22, 2022
Lahari gave a flawless presentation of her research at the North Carolina School of Science and Mathematics Summer Mentorship Celebration Symposium. You can view a recreation
of her 3-minute talk on youtube.
June 7, 2022
Nila was invited to give a talk at the Gordon Research Seminar (GRS) on Meiosis, held at Colby-Sawyer College. This conference is a prelude to the Gordon Research Conference
(GRC) held immediately after. The GRS showcases resaerch by trainees. Nila and Carolyn both presented posters at the GRS and the GRC.
February 11, 2022
The BBSP graduate program selected our lab manager, Susan Cheek, to receive a 2021-22 Science Mentoring Award.
This is the first year the award was opened to allow nominations of staff. Susan has contributed to the professional and personal development of essentially every former lab member, from
undergraduates to postdoctoral fellows.