Talia Hatkevich

Graduate Student, Curriculum in Genetics and Molecular Biology
B.S. University of Pittsburgh (2007)
M.S. UNC Greensboro (2013)
started in the lab March 2014

Research Interests

Crossovers (COs) between homologous chromosomes ensure proper meiosis I segregation; failure to produce a CO results in nondisjunction and sterility. Although CO formation is tightly controlled, the mechanisms that implement genome-wide COs remain poorly understood. I am interested in examining CO control mechanisms such as interference, homeostasis, and distribution using Drosophila as a model. In a second project, I am examining the connection between chromosome dynamics, the arcitecture of the nucleus, and recombination.

Publications from research in the Sekelsky Lab

• T. Hatkevich, J. Sekelsky (2017) Bloom syndrome helicase in meiosis: Pro-crossover functions of an anti-crossover protein. Bioessays 39: 1-11. DOI: 10.1002/bies.201700073.
   
• T. Hatkevich*, K. Kohl*, S. McMahan, M. Hartmann, A. Williams, J. Sekelsky (2017) Blm helicase promotes meiotic crossover patterning and homolog disjunction. Current Biology 27: 1-5. DOI: 10.1016/j.cub.2016.10.055
   
• J.K. Holsclaw*, T. Hatkevich*, and J. Sekelsky (2016) Meiotic and Mitotic Recombination: First in Flies, in Genome Stability: From Virus to Human Application. Kovalchuk and Kovalchuk, eds., Academic Press.
   

Awards

• NIGMS T32 NRSA in Genetics appointment (2014-15).
• NRSA F31 fellowship from National Institute of Aging (2016-18).

Invited Talks

• "Exploring the Importance of Class I Crossovers in Meiosis"
  UNC-Greensboro Deptartment of Biology Seminar Series (2017).
• "Proposing a Novel Role for Centromere-Specific SMC1 in Drosophila Prophase I"
  EMBO Conference on Meiosis, Hvar Croatia (Aug 2017).

Leadership Roles

• Co-Chair, Gordon-Kenan Research Seminar on Meiosis (2016).
• Organizing Committee, Triangle Fly Meeting (2015).