My interest in meiosis began in graduate school, where I studied the effects of a mutation in the FHA domain of Nbs1 on meiotic recombination, using the mushroom Coprinus cinereus as a model system. Currently, I am interested in exploring how crossovers and noncrossovers arise from the same initiating event, DNA double-strand breaks. I am working on a project to eliminate both canonical mismatch repair and the lesser known short-patch mismatch repair. I will be able to detect heteroduplex DNA that is formed during meiotic recombination and then make hypotheses about how crossovers and noncrossovers arise from DSBs. Additionally, to ask questions about how gene conversion occurs, I am constructing compound chromosomes in which the arms of homologous chromosomes are attached to the same centromere. I can then do half-tetrad analysis and ask about the location and lengths of gene conversion tracts.
Publications from research in the Sekelsky Lab
The background of this page is some shrooms (Coprinus cinereus).
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