Graduate Student, Curriculum in Genetics and Molecular Biology
Crossovers (COs) between homologous chromosomes ensure proper meiosis I segregation, but to do so they must be in the right places along the chromosome. Crossovers near the centromere can disrupt segregation and are a common cause of nondisjunction of chromosome 21 that leads to Down Syndrome. In many animals there is a strong "centromere effect" that prevents crossovers too close to the centromere. I am using Drosophila melanogaster, the organism in which this phenomenon was first discovered, to elucidate properties and mechanisms of the centromere effect.
Publications from research in the Sekelsky Lab