Julie Korda Holsclaw

Graduate Student, Curriculum in Genetics and Molecular Biology
B.S. University of Colorado (2010)
started in the lab January 2012

Research Interests

Cells use a variety of pathways to repair DNA damage, but how the genome is repaired when DNA is actively replicating is poorly understood. DNA repair during replication contributes to chemotherapeutic resistance, and compromised repair during replication is responsible for many rare genetic diseases. Replication fork remodeling is a key process in damage-associated repair during replication, but the proteins that are responsible for fork regression and subsequent resolution of regressed intermediates to facilitate restart remain unknown. My research tests the roles and redundancy of two candidate helicases, Marcal1 and Blm, in replication fork remodeling, using classical Drosophila genetics as well as modern molecular techniques.

Publications from research in the Sekelsky Lab

• J.K. Holsclaw*, T. Hatkevich*, and J. Sekelsky (2016) Meiotic and Mitotic Recombination: First in Flies, in Genome Stability: From Virus to Human Application. Kovalchuk and Kovalchuk, eds., Academic Press.
   
• M.C. LaFave., S.L. Andersen, E.P. Stoffregen, J.K. Holsclaw, K.P. Kohl, L.J. Overton, and J. Sekelsky (2013) Sources and structures of mitotic crossovers that arise when BLM helicase is absent in Drosophila. Genetics 196: 107-118.
   
• C.M. Lake, J.K. Holsclaw, S.P. Bellendir, J. Sekelsky, and R.S. Hawley (2013) The development of a monoclonal antibody recognizing the Drosophila melanogaster phosphorylated histone H2A variant (γH2AV). G3 4: 1539-1543..
   

Awards

• NRSA F31 fellowship from National Institute of General Medical Sciences (2015-16).