SPIRE Postdoctoral Fellow
I am investigating the role of the Drosophila BLM protein in the early embryo.
BLM is a DNA helicase that acts to prevent mitotic crossover and can resolve problematic replication forks
during DNA replication. BLM is essential in early embryonic development; there is a requirement for
maternally loaded BLM prior to the start of zygotic transcription. Therefore, BLM mutant females have a
high rate of sterility and the embryos from these mutant mothers show severe nuclear defects. I am exploring
whether BLM functions to prevent replication fork problems during the rapid DNA replication cycles
in the early Drosophila embryo.
Publications from research in the Sekelsky Lab